COPB1 Antibody
Product Specifications
Background
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
NCBI Gene ID
1315
Swiss Prot
P53618
Accession Number
NP_057535
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human COPB1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10409 - Fetal Liver Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store COPB1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
107 kDa
Applications Notes
COPB1 antibody can be used for detection of COPB1 by ELISA at 1:12500. COPB1 antibody can be used for detection of COPB1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
COPB1
NCBI Official Name
Coatomer protein complex, subunit beta 1
NCBI Organism
Homo sapiens
Background Reference 01
Goryachev, A.B. PLoS Comput. Biol. 2 (12), E172 (2006) .
Other Product Names
COPB1, COPB, DKFZp761K102, FLJ10341
Tested Applications
ELISA, WB
Protein ID
7705369
Physical Properties
Liquid
Curated Selection
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