NAT2 Antibody
Product Specifications
Background
NAT2 is a N-acetyltransferase 2 (arylamine N-acetyltransferase 2) . This enzyme functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in its gene are reponsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in NAT2 are also associated with higher incidences of cancer and drug toxicity.This gene encodes N-acetyltransferase 2 (arylamine N-acetyltransferase 2) . This enzyme functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are reponsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in NAT2 are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near NAT2.
NCBI Gene ID
10
Swiss Prot
P11245
Accession Number
NP_000006
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NAT2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Cancer
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store NAT2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
32 kDa
Applications Notes
NAT2 antibody can be used for detection of NAT2 by ELISA at 1:312500. NAT2 antibody can be used for detection of NAT2 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
NAT2
NCBI Official Name
N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCBI Organism
Homo sapiens
Background Reference 01
Tamer, L., (2006) Cell Biochem. Funct. 24 (2), 131-135.
Other Product Names
NAT2, AAC2, PNAT, NAT-2
Tested Applications
ELISA, WB
Protein ID
116295260
Physical Properties
Liquid
Curated Selection
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