STEAP3 Antibody
Product Specifications
Background
AS an endosomal ferrireductase, STEAP3 is required for efficient transferrin-dependent iron uptake in erythroid cells. It participates in erythroid iron homeostasis by reducing Fe (3+) to Fe (2+) and can also reduce of Cu (2+) to Cu (1+), suggesting that it participates in copper homeostasis. STEAP3 uses NAD (+) as acceptor (By similarity) . It may play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. STEAP3 is indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCT.
NCBI Gene ID
55240
Swiss Prot
A8K6E3
Accession Number
NP_878919
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human STEAP3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Cancer
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10409 - Fetal Liver Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store STEAP3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
56 kDa
Applications Notes
STEAP3 antibody can be used for detection of STEAP3 by ELISA at 1:312500. STEAP3 antibody can be used for detection of STEAP3 by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
STEAP3
NCBI Official Name
STEAP family member 3, metalloreductase
NCBI Organism
Homo sapiens
Background Reference 01
Sendamarai, A.K., (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (21), 7410-7415.
Other Product Names
STEAP3, STMP3, TSAP6, dudlin-2, AHMIO2
Tested Applications
ELISA, WB
Protein ID
56549145
Physical Properties
Liquid
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