MSH2 Antibody
Product Specifications
Background
MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC.
NCBI Gene ID
4436
Swiss Prot
P43246
Accession Number
AAY15096
Host
Rabbit
Reactivity
Human, Mouse, Dog, Zebrafish
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MSH2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Cancer, Apoptosis
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store MSH2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
64 kDa, 105 kDa
Applications Notes
MSH2 antibody can be used for detection of MSH2 by ELISA at 1:62500. MSH2 antibody can be used for detection of MSH2 by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
MSH2
NCBI Official Name
MutS homolog 2
NCBI Organism
Homo sapiens
Background Reference 01
Hoss, M. EMBO J. (1999) 18 (13), 3868-3875.
Other Product Names
MSH2, FCC1, COCA1, HNPCC, LCFS2, HNPCC1
Tested Applications
ELISA, WB
Protein ID
62822548
Physical Properties
Liquid
Curated Selection
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