MCM6 Antibody
Product Specifications
Background
The protein encoded by the MCM6 gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.
NCBI Gene ID
4175
Swiss Prot
Q14566
Accession Number
NP_005906
Host
Rabbit
Reactivity
Human, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MCM6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Cancer
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store MCM6 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=28-537
Calculated Molecular Weight
90 kDa
Applications Notes
MCM6 antibody can be used for detection of MCM6 by ELISA at 1:312500. MCM6 antibody can be used for detection of MCM6 by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
MCM6
NCBI Official Name
Minichromosome maintenance complex component 6
NCBI Organism
Homo sapiens
Background Reference 01
Kimura, K., (2006) Genome Res. 16 (1), 55-65.
Other Product Names
MCM6, MCG40308, Mis5, P105MCM
Tested Applications
ELISA, WB, IHC
Protein ID
7427519
Physical Properties
Liquid
Curated Selection
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