ALG1 Antibody
Product Specifications
Background
ALG1 catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. Defects in ALG1 are the cause of congenital disorder of glycosylation type 1K (CDG1K) .The biosynthesis of lipid-linked oligosaccharides is highly conserved among eukaryotes and is catalyzed by 14 glycosyltransferases in an ordered stepwise manner. Mannosyltransferase I (MT I) catalyzes the first mannosylation step in this process.
NCBI Gene ID
56052
Swiss Prot
Q9BT22
Accession Number
NP_061982
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ALG1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Signal Transduction
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
NTERA2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ALG1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
52 kDa
Applications Notes
ALG1 antibody can be used for detection of ALG1 by ELISA at 1:62500. ALG1 antibody can be used for detection of ALG1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
ALG1
NCBI Official Name
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
NCBI Organism
Homo sapiens
Background Reference 01
Grubenmann, C.E., (2004) Hum. Mol. Genet. 13 (5), 535-542.
Other Product Names
ALG1, HMAT1, HMT-1, HMT1, MT-1, CDG1K, Mat-1, hMat-1
Tested Applications
ELISA, WB
Protein ID
41350216
Physical Properties
Liquid
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