PFKFB2 Antibody

Product Specifications

Background

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.

NCBI Gene ID

5208

Swiss Prot

O60825

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 446-505 of human PFKFB2 (NP_006203.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

Affinity purification

Positive Control

A-549

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 54kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

PFKFB2

Positive Control 2

Mouse liver

Positive Control 3

Mouse brain

Positive Control 4

Mouse skeletal muscle

Positive Control 5

Rat liver

NCBI Official Name

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

NCBI Organism

Homo sapiens

Other Product Names

PFKFB2, fructose-2, 6-bisphosphatase, cardiac isozyme, PFKFB, cardiac, OTTHUMP00000034286, OTTHUMP00000034285, 6PF-2-K/Fru-2, 6-P2ASE heart-type isozyme, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2, PFK-2/FBPase-2, MGC138310, MGC138308, DKFZp781D2217, 6-biphosphatase 2, PFKFB2