OCRL Antibody
Product Specifications
Background
This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants.
NCBI Gene ID
4952
Swiss Prot
Q01968
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human OCRL (NP_001578.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
U-251MG
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 110kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
OCRL
Positive Control 2
A-549
Positive Control 3
22Rv1
Positive Control 4
Mouse brain
Positive Control 5
Mouse lung
Positive Control 6
Rat brain
NCBI Official Name
Oculocerebrorenal syndrome of Lowe
NCBI Organism
Homo sapiens
Other Product Names
OCRL, NPHL2, OCRL-1, LOCR, OCRL1
Tested Applications
WB
Physical Properties
Liquid
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