GCA Antibody
Product Specifications
Background
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.
NCBI Gene ID
25801
Swiss Prot
P28676
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human GCA (NP_036330.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Positive Control
HL-60
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 24kDa
Fragment
IgG
Symbol
GCA
Positive Control 2
HT-29
Positive Control 3
Mouse kidney
Positive Control 4
Mouse heart
NCBI Official Name
Grancalcin, EF-hand calcium binding protein
NCBI Organism
Homo sapiens
Other Product Names
GCL, Grancalcin, GCL
Tested Applications
WB, IF
Physical Properties
Liquid
Curated Selection
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