CD207 Antibody

Product Specifications

Background

The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity.

NCBI Gene ID

50489

Swiss Prot

Q9UJ71

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 69-328 of human CD207 (NP_056532.4) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Immunology, Signal Transduction

Purification

Affinity purification

Positive Control

HT-29

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 37kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

CD207

Positive Control 2

HepG2

Positive Control 3

Mouse liver

NCBI Official Name

CD207 molecule

NCBI Organism

Homo sapiens

Other Product Names

CLEC4K, C-type lectin domain family 4 member K, C-type lectin domain family 4, member K, CD207 antigen, langerin, CD207 molecule, langerin, Langerhans cell specific c-type lectin