NR2C2 Antibody
Product Specifications
Background
This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms.
NCBI Gene ID
7182
Swiss Prot
P49116
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 240-380 of human NR2C2 (NP_003289.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Immunology, Transcription
Purification
Affinity purification
Positive Control
MCF7
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 65kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
NR2C2
Positive Control 2
HeLa
Positive Control 3
Jurkat
Positive Control 4
293T
Positive Control 5
Mouse brain
Positive Control 6
Mouse spleen
NCBI Official Name
Nuclear receptor subfamily 2, group C, member 2
NCBI Organism
Homo sapiens
Other Product Names
NR2C2, TAK1, TR2R1, TR4, hTAK1
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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