PC Antibody
Product Specifications
Background
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.
NCBI Gene ID
5091
Swiss Prot
P11498
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 879-1178 of human PC (NP_001035806.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
HepG2
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 129kDa
Fragment
IgG
Symbol
PC
Positive Control 2
HeLa
Positive Control 3
MCF7
Positive Control 4
A-549
Positive Control 5
U-251MG
Positive Control 6
Mouse liver
NCBI Official Name
Pyruvate carboxylase
NCBI Organism
Homo sapiens
Other Product Names
PC, pyruvate carboxylase, PCB
Tested Applications
WB, IF
Physical Properties
Liquid
Curated Selection
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