ING3 Antibody
Product Specifications
Background
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
NCBI Gene ID
54556
Swiss Prot
Q9NXR8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-92 of human ING3 (NP_938008.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
Affinity purification
Positive Control
293T
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 50kDa
Fragment
IgG
Symbol
ING3
Positive Control 2
SW620
Positive Control 3
HeLa
Positive Control 4
Rat testis
NCBI Official Name
Inhibitor of growth family, member 3
NCBI Organism
Homo sapiens
Other Product Names
ING3, Eaf4, FLJ20089, ING2, p47ING3, MEAF4
Tested Applications
WB, IF
Physical Properties
Liquid
Curated Selection
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