CDKN2B Antibody
Product Specifications
Background
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
NCBI Gene ID
1030
Swiss Prot
P42772
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-138 of human CDKN2B (NP_004927.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction, Stem Cell
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 15kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
CDKN2B
Positive Control 2
SW620
Positive Control 3
A-549
NCBI Official Name
Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
NCBI Organism
Homo sapiens
Other Product Names
CDKN2B, P15, MTS2, TP15, CDK4I, INK4B, p15INK4b
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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