DOCK2 Antibody
Product Specifications
Background
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP.
NCBI Gene ID
1794
Swiss Prot
Q92608
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1551-1830 of human DOCK2 (NP_004937.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction, Stem Cell
Purification
Affinity purification
Positive Control
Jurkat
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 240kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:1000
Symbol
DOCK2
NCBI Official Name
Dedicator of cytokinesis 2
NCBI Organism
Homo sapiens
Other Product Names
IMD4dedicator of cytokinesis protein 2, dedicator of cyto-kinesis 2
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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