CHD3 Antibody

Product Specifications

Background

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

NCBI Gene ID

1107

Swiss Prot

Q12873

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1900-2000 of human CHD3 (NP_001005273.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

Affinity purification

Positive Control

Jurkat

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 280kDa

Fragment

IgG

Applications Notes

WB: 1:200 - 1:1000

Symbol

CHD3

Positive Control 2

Mouse brain

Positive Control 3

Rat brain

NCBI Official Name

Chromodomain helicase DNA binding protein 3

NCBI Organism

Homo sapiens

Other Product Names

Mi-2a, Mi2-ALPHA, SNIBCPS, ZFH, chromodomain-helicase-DNA-binding protein 3, ATP-dependent helicase CHD3, CHD-3, hZFH, mi-2 autoantigen 240 kDa protein, zinc finger helicase, zinc-finger helicase (Snf2-like)