EIF4E Antibody
Product Specifications
Background
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
1977
Swiss Prot
P06730
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human EIF4E (NP_001959.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
Affinity purification
Positive Control
HL-60
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 25kDa
Fragment
IgG
Symbol
EIF4E
Positive Control 2
SW620
Positive Control 3
MCF-7
Positive Control 4
293T
Positive Control 5
Mouse brain
Positive Control 6
Rat testis
NCBI Official Name
Eukaryotic translation initiation factor 4E
NCBI Organism
Homo sapiens
Other Product Names
Eukaryotic translation initiation factor 4E, eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein, EIF4E, EIF4EL1, EIF4F
Tested Applications
WB, IHC, IF, IP
Physical Properties
Liquid
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