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PDCD10 Antibody, KO Validated

Product Specifications

Background

This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.

NCBI Gene ID

11235

Swiss Prot

Q9BUL8

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human PDCD10 (NP_009148.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Antibody is Knockout validated.

Field of Research

Apoptosis, Cell Cycle, Neuroscience, Signal Transduction

Purification

Affinity purification

Positive Control

A-431

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=16-032

Calculated Molecular Weight

Observed: 26kDa

Fragment

IgG

Symbol

PDCD10

Positive Control 2

HepG2

Positive Control 3

Jurkat

Positive Control 4

MCF7

Positive Control 5

Mouse thymus

Positive Control 6

Mouse brain

NCBI Official Name

Programmed cell death protein 10

NCBI Organism

Homo sapiens

Other Product Names

Programmed cell death protein 10, Cerebral cavernous malformations 3 protein, TF-1 cell apoptosis-related protein 15, PDCD10, CCM3, TFAR15

Tested Applications

WB, IF

Physical Properties

Liquid

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