POT1 Antibody
Product Specifications
Background
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
NCBI Gene ID
25913
Swiss Prot
Q9NUX5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 497-634 of human POT1 (NP_056265.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
Affinity purification
Positive Control
A-431
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 75kDa
Fragment
IgG
Symbol
POT1
Positive Control 2
HeLa
Positive Control 3
DU145
Positive Control 4
Mouse liver
NCBI Official Name
Protection of telomeres 1
NCBI Organism
Homo sapiens
Other Product Names
CMM1GLM9, HPOT1, protection of telomeres protein 1, POT1-like telomere end-binding protein, protection of telomeres 1 homolog
Tested Applications
WB, IHC
Physical Properties
Liquid
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