GREM2 Antibody

Product Specifications

Background

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.

NCBI Gene ID

64388

Swiss Prot

Q9H772

Host

Rabbit

Reactivity

Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human GREM2 (NP_071914.3) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Chemokines & Cytokines, Immunology, Signal Transduction, Stem Cell

Purification

Affinity purification

Positive Control

Mouse brain

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 19kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

GREM2

NCBI Official Name

Gremlin 2, DAN family BMP antagonist

NCBI Organism

Homo sapiens

Other Product Names

CKTSF1B2, DAND3, PRDC, STHAG9, gremlin-2, DAN domain family member 3, cysteine knot superfamily 1, BMP antagonist 2, gremlin 2, cysteine knot superfamily, homolog, protein related to DAN and cerberus