UPF1 Antibody
Product Specifications
Background
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD) . When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
5976
Swiss Prot
Q92900
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 270-370 of human UPF1 (NP_002902.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cell Cycle
Purification
Affinity purification
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Fragment
IgG
Symbol
UPF1
NCBI Official Name
UPF1 regulator of nonsense transcripts homolog (yeast)
NCBI Organism
Homo sapiens
Other Product Names
UPF1, FLJ43809, FLJ46894, HUPF1, KIAA0221, NORF1, RENT1, pNORF1, smg-2
Tested Applications
WB, IHC
Physical Properties
Liquid
Curated Selection
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