UPF2 Antibody

Product Specifications

Background

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD) . When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.

NCBI Gene ID

26019

Swiss Prot

Q9HAU5

Host

Rabbit

Reactivity

Human, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1153-1272 of human UPF2 (NP_542166.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Affinity purification

Positive Control

MCF7

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 180kDa

Fragment

IgG

Symbol

UPF2

Positive Control 2

HT-29

Positive Control 3

Jurkat

Positive Control 4

HepG2

Positive Control 5

HeLa

NCBI Official Name

UPF2 regulator of nonsense transcripts homolog (yeast)

NCBI Organism

Homo sapiens

Other Product Names

UPF2, UPF2 regulator of nonsense transcripts homolog (yeast), HGNC:17854, DKFZP434D222, HUPF2, KIAA1408, RENT2, OTTHUMP00000045025, UPF2 regulator of nonsense transcripts homolog, regulator of nonsense transcripts 2, yeast Upf2p homolog