DKC1 Antibody
Product Specifications
Background
This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs) . This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
1736
Swiss Prot
O60832
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human DKC1 (NP_001354.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 57kDa
Fragment
IgG
Symbol
DKC1
Positive Control 2
22Rv1
Positive Control 3
HepG2
Positive Control 4
MCF7
Positive Control 5
K-562
NCBI Official Name
Dyskeratosis congenita 1, dyskerin
NCBI Organism
Homo sapiens
Other Product Names
DKC1, dyskeratosis congenita 1, dyskerin, DKC, NAP57, NOLA4, XAP101
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
Curated Selection
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