PPP1CA Antibody
Product Specifications
Background
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1) . PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
5499
Swiss Prot
P62136
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human PPP1CA (NP_002699.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
DU145
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 38kDa
Fragment
IgG
Symbol
PPP1CA
Positive Control 2
MCF7
Positive Control 3
NIH3T3
Positive Control 4
HepG2
Positive Control 5
Mouse brain
NCBI Official Name
Protein phosphatase 1, catalytic subunit, alpha isozyme
NCBI Organism
Homo sapiens
Other Product Names
PPP1CA, MGC15877, MGC1674, PP-1A, PPP1A, PP1A, PP1alpha
Tested Applications
WB, IHC
Physical Properties
Liquid
Curated Selection
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