CRKL Antibody, KO Validated
Product Specifications
Background
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
NCBI Gene ID
1399
Swiss Prot
P46109
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human CRKL (NP_005198.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Antibody is Knockout validated.
Field of Research
Cancer, Immunology, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
LO2
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 37kDa
Fragment
IgG
Symbol
CRKL
Positive Control 2
Jurkat
Positive Control 3
SKOV3
Positive Control 4
Mouse brain
Positive Control 5
Rat heart
NCBI Official Name
V-crk avian sarcoma virus CT10 oncogene homolog-like
NCBI Organism
Homo sapiens
Other Product Names
CRKL, v-crk sarcoma virus CT10 oncogene homolog (avian) -like, v-crk avian sarcoma virus CT10 oncogene homolog-like
Tested Applications
WB, IF
Physical Properties
Liquid
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