MTMR3 Antibody

Product Specifications

Background

This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol (3) -phosphate and phosphatidylinositol (3,5) -biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

8897

Swiss Prot

Q13615

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 640-810 of human MTMR3 (NP_066576.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Autophagy, Cell Cycle, Signal Transduction

Purification

Affinity purification

Positive Control

U-87MG

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 134kDa

Fragment

IgG

Symbol

MTMR3

Positive Control 2

HeLa

Positive Control 3

Jurkat

Positive Control 4

LO2

NCBI Official Name

Myotubularin related protein 3

NCBI Organism

Homo sapiens

Other Product Names

FYVE-DSP1, ZFYVE1myotubularin-related protein 3, FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity protein phosphatase, FYVE domain-containing dual specificity protein phosphatase 1, phosphatidylinositol-3,5-bisphosphate 3-phosphatase, phosphatidylinositol-3-phosphate phosphatase, zinc finger FYVE domain-containing protein 1zinc finger, FYVE domain containing 10