IARS Antibody
Product Specifications
Background
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found.
NCBI Gene ID
3376
Swiss Prot
P41252
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1158-1262 of human IARS (NP_002152.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 144kDa
Fragment
IgG
Symbol
IARS
Positive Control 2
HepG2
Positive Control 3
HT-29
Positive Control 4
HL-60
Positive Control 5
Jurkat
NCBI Official Name
Isoleucyl-tRNA synthetase
NCBI Organism
Homo sapiens
Other Product Names
GRIDHH1, ILERS, ILRS, IRS, PRO0785, IARS, isoleucine--tRNA ligase, cytoplasmic, isoleucine tRNA ligase 1, cytoplasmic
Tested Applications
WB, IHC
Physical Properties
Liquid
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