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DIS3L2 Antibody

Product Specifications

Background

The exosome is involved in a multitude of cellular RNA processing and degradation events (1) . DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species (2) . DIS3L2 is a paralog of DIS3, but unlike DIS3 is located in the cytoplasm (3) . DIS3L2 defines a novel eukaryotic RNA degradation pathway and preferentially targets uridylated RNA (4) . DIS3L2 mutations have also been associated with sporadic Wilms tumors (3) .

NCBI Gene ID

129563

Swiss Prot

Q8IYB7

Accession Number

NP_689596

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

DIS3L2 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1282 - 3T3 (NIH) Cell Lysate

Concentration

1 mg/mL

Buffer

DIS3L2 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

DIS3L2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=8347

Fragment

IgG

Specificity

DIS3L2 antibody is human, mouse and rat reactive. At least three isoforms of DIS3L2 are known to exist; this antibody will only detect the longest isoform. DIS3L2 is predicted to not cross-react with DIS3 or DIS3L.

Symbol

DIS3L2

NCBI Official Name

DIS3 like 3'-5' exoribonuclease 2

NCBI Organism

Homo sapiens

Background Reference 01

Chen CY, Gherzi R, Ong SE, et al. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell 2001; 107:451-64.

Background Reference 02

Brouwer R, Allmang C, Raijmakers R, et al. Three novel components of the human exosome. J. Biol. Chem. 2001; 276:6177-84.

Background Reference 03

Astuti D, Morris MR, Cooper WN, et al. Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility. Nat. Genet. 2012; 44:277-84.

Background Reference 04

Malecki M, Viegas SC, Carneiro T, et al. The exonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway. EMBO J. 2013; 32:1842-54.

Other Product Names

DIS3 like 3'-5' exoribonuclease 2, FAM6A, PRLMNS

Tested Applications

ELISA, WB

Protein ID

134288890

Physical Properties

Liquid

Available Sizes

Curated Selection

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