IQSEC2 Antibody

Product Specifications

Background

ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. Similar to the related protein IQSEC1, IQSEC2 is a guanine nucleotide exchange protein for ARF1 and ARF6 that belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1,2) . IQSEC2 is a major component of the postsynaptic density (PSD) and colocalizes with PSD-95. It has been suggested to modulate the functions of the ARF proteins (1) . Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation (3) .

NCBI Gene ID

23096

Swiss Prot

Q5JU85

Accession Number

NP_001104595

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

IQSEC2 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1220 - SK-N-SH Cell Lysate

Concentration

1 mg/mL

Buffer

IQSEC2 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

IQSEC2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

IQSEC2 antibody is human, mouse and rat reactive. At least two isoforms of IQSEC2 are known to exist; this antibody will only detect the larger isoform. IQSEC2 antibody is predicted to not cross-react with IQSEC1.

Symbol

IQSEC2

NCBI Official Name

IQ motif and Sec7 domain 2

NCBI Organism

Homo sapiens

Background Reference 01

Murphy JA, Jensen ON, and Walikonis RS. BRAG1, a SEC7 domain-containing protein, is a component of the postsynaptic density of excitatory synapses. Brain Res. 2006; 1120:35-45.

Background Reference 02

Someya A, Sata M, Takeda K, et al. ARF-GEP (100), a guanine nucleotide-exchange protein for ADP-ribosy

Background Reference 03

Shoubridge C, Tarpey PS, Abidi F, et al. Mutations in the guanine nucleotide exchange factor gene IQSEC2 cause nonsyndromic intellectual ability. Nat. Genet. 2010; 42:486-8.