SKI2W Antibody

Product Specifications

Background

SKI2W (SKIV2L, Helicase-like protein), a DEVH-box protein, is a component of the SKI complex which is involved in the regulation of translation and RNA turnover (1,2) . SKI2W is a nucleolar and cytoplasmic protein that has a putative RNA helicase domain (2) . The potential roles of Ski2W on the clearance of degraded nuclear and cytoplasmic RNA raised their possibilities as susceptibility genes of systemic lupus erythematosus (3,4) .

NCBI Gene ID

6499

Swiss Prot

Q15477

Accession Number

NP_008860

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

SKI2W antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1415 - Mouse Stomach Tissue Lysate

Concentration

1 mg/mL

Buffer

SKI2W antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SKI2W antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

SKI2W antibody is human, mouse and rat reactive. At least two isoforms of SKI2W are known to exist; this antibody will detect both isoforms.

Symbol

SKIV2L

Positive Control 2

Cat. No. 10-801 - Human Stomach Tissue Slide

NCBI Official Name

SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)

NCBI Organism

Homo sapiens

Background Reference 01

Dangel AW, Shen L, Mendoza AR, et al. Human helicase gene SKI2W in the HLA class III region exhibits striking structural similarities to the yeast antiviral gene SKI2 and to the human gene KIAA0052: emergence of a new gene family. Nucleic Acids Res. 1995; 23:2120-6.

Background Reference 02

Qu X, Yang Z, Zhang S, et al. The human DEVH-box protein Ski2w from the HLA is localized in nucleoli and ribosomes. Nucleic Acids Res. 1998; 26:4068-77.

Background Reference 03

Yang Z, Shen L, Dangel AW, et al. Four ubiquitously expressed genes, RD (D6S45) -SKI2W (SKIV2L) -DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA. Genomics 1998; 53:338-47.

Background Reference 04

Yang Z, Qu X, and Yu CY. Features of the two gene pairs RD-SKI2W and DOM3Z-RP1 located between complement component genes factor B and C4 at the MHC class III region. Front. Biosci. 2001; 6:D927-35.