KIRREL2 Antibody

Product Specifications

Background

KIRREL2, also known as nephrin-like 3, is a type I transmembrane protein belonging to the immunoglobulin superfamily of cell adhesion molecules (1) . KIRREL2 consists of five extracellular Ig-like repeats, a transmembrane domain, several glycosylation sites and a cytoplasmic domain that has a stretch of nine conserved residues (1,2) . KIRREL2 has been found to be expressed in beta cells of pancreatic islets and is involved in the regulation of both glomerular and neural development (3,4) . Downregulation of KIRREL2 is implicated in several proteinuric diseases (4,5) .

NCBI Gene ID

84063

Swiss Prot

Q6UWL6

Accession Number

NP_954649

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Stem Cell

Purification

KIRREL2 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1210 - HEK293 Cell Lysate

Concentration

1 mg/mL

Buffer

KIRREL2 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

KIRREL2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

KIRREL2 antibody is human, mouse and rat reactive. At least five isoforms are are known to exist. This antibody is predicted to not cross-react with other members of the KIRREL protein family.

Symbol

KIRREL2

Positive Control 2

Cat. No. 11-101 - Human Pancreas Tissue Slide

NCBI Official Name

Kin of IRRE like 2 (Drosophila)

NCBI Organism

Homo sapiens

Background Reference 01

Sun C, Kilburn D, Lukashin A, et al. KIRREL2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets. Genomics 2003; 82:130-42.

Background Reference 02

Heikkila E, Ristola M, Havana M, et al. Trans-interaction of nephrin and Neph1/Neph3 induces cell adhesion that associates with decreased tyrosine phosphorylation of nephrin. Biochem. J. 2011; 435:619-28.

Background Reference 03

Wang H, Lehtonen S, Chen YC, et al. Neph3 associates with regulation of glomerular and neural development in zebrafish. Differentiation 2012; 83:38-46.

Background Reference 04

Mizuhara E, Minaki Y, Nakatani T, et al. Purkinje cells originate from cerebellar ventricular zone progenitors positive for Neph3 and E-cadherin. Dev. Biol. 2010; 338:202-14.