E2F3 Antibody

Product Specifications

Background

The E2F transcription factor 3 (E2F3) is a member of a small family of transcription factors that function through binding of DP interaction partner proteins. E2F3 recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle (1) . Like the related E2F1 and E2F2, E2F3 is essential for cellular proliferation and progression through the cell cycle (2) . Altered copy number and activity of this gene have been observed in a number of human cancers (3) .

NCBI Gene ID

1871

Swiss Prot

O00716

Accession Number

NP_001940

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

E2F3 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1369 - Human Lymph node Tissue Lysate

Concentration

1 mg/mL

Buffer

E2F3 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

E2F3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

E2F3 antibody is human and mouse reactive. At least three isoforms of E2F3 are known to exist; this antibody will detect only the largest isoform. This antibody is predicted to not cross-react with other members of the E2F transcription factor family.