PDCL Antibody

Product Specifications

Background

Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling (1,2) . PDCL is widely expressed in normal human tissues and may participate directly in the regulation of calcium-evoked exocytosis in adrenal medullary chromaffin cells (3) . It is an ethanol-responsive modulator of heterotrimeric G proteins (4) .

NCBI Gene ID

5082

Swiss Prot

Q13371

Accession Number

NP_005379

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

PDCL antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1204 - K562 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (94%)

Buffer

PDCL antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PDCL antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

PDCL antibody is human, mouse and rat reactive. At least two isoforms of PDCL are known to exist. PDCL antibody is predicted to not cross-react with other members of the PDCL protein family.

Symbol

PDCL

NCBI Official Name

Phosducin-like

NCBI Organism

Homo sapiens

Background Reference 01

Miles MF, Barhite S, Sganga M, et al. Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function. Proc. Natl. Acad. Sci. USA 1993; 90:10831-5.

Background Reference 02

Ruiz-Gomez A, Humrich J, Murga C, et al. Phosphorylation of phosducin and phosducinlike protein by G protein-coupled receptor kinase 2. J. Biol. Chem. 2000; 275:29724-30.

Background Reference 03

Gensse M, Vitale N, Chasserot-Golaz S, et al. Regulation of exocytosis in chromaffin cells by phosducin-like protein, a protein interacting with G protein betagamma-subunits. FEBS Lett. 2000; 480:184-8.

Background Reference 04

Barhite S, Thibault C, Miles MF, et al. Phosducin-like protein (PhLP), a regulator of G beta gamma function, interacts with the proteasomal protein SUG1. Biochim. Biophys. Acta 1998; 1402: 95-101.