WFDC2 Antibody

Product Specifications

Background

The WAP four-disulfide core domain protein 2 (WFDC2), also known as epididymal protein 4, is a member of the WFDC domain family, a family of proteins that is characterized by the presence of Whey Acidic Protein (WAP) domain, and is highly expressed in the lung and salivary gland (1,2) . Members of this family include SLPI and elafin, antiproteinases involved in the innate immune system (2) . WFDC2 has been proposed to play a critical role in tumor formation and growth in ovarian cancer cells through the regulation of growth- and apoptosis-associated genes and may thus be a potential therapeutic target for epithelial ovarian cancer (3) .

NCBI Gene ID

10406

Swiss Prot

Q14508

Accession Number

NP_006094

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis

Purification

WFDC2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1203 - A549 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rabbit: (73%)

Buffer

WFDC2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

WFDC2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

WFDC2 antibody is human specific. Multiple isoforms of WFDC2 are known to exist.

Symbol

WFDC2

Positive Control 2

Cat. No. 10-101 - Human Lung Tissue Slide

NCBI Official Name

WAP four-disulfide core domain 2

NCBI Organism

Homo sapiens

Background Reference 01

Drapkin R, von Horsten HH, Lin Y, et al. Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serious and endometrioid ovarian carcinomas. Cancer Res. 2005; 65:2162-9.

Background Reference 02

Bingle L, Cross SS, High AS, et al. WFDC2 (HE4) : A potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung. Resp. Res. 2006; 7:61.

Background Reference 03

Chen Y, Mu X, Wang S, et al. WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes. Oncol. Rep. 2013; 29:288-96.