TFPI Antibody

Product Specifications

Background

TFPI Antibody: Tissue factor pathway inhibitor (TFPI), also known as lipoprotein-associated coagulation inhibitor, is a protease inhibitor that regulates the tissue factor (TF) -dependent pathway of blood coagulation (1) . TFPI is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop (1) .

NCBI Gene ID

7035

Swiss Prot

P10646

Accession Number

NP_006278

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

TFPI Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1468 - Rat Small Intestine Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rabbit: (92%)

Buffer

TFPI Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TFPI antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

TFPI antibody is human, mouse and rat reactive. At least two isoforms of TFPI are known to exist; this antibody will detect both isoforms.

Symbol

TFPI

NCBI Official Name

Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

NCBI Organism

Homo sapiens

Background Reference 01

Broze GJ Jr and Girard TJ. Tissue factor pathway inhibitor: structure-function. Front. Biosci. 17:262-80.

Other Product Names

TFPI Antibody: EPI, TFI, LACI, TFPI1, Tissue factor pathway inhibitor, Extrinsic pathway inhibitor, TFPI

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

5454114

Physical Properties

Liquid

Available Sizes

Curated Selection

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