ERRF Antibody

Product Specifications

Background

ERRF Antibody: The estrogen receptor-related factor (ERRF) is a recently identified protein whose expression is upregulated in multiple cell lines and primary breast cancer tumors. Increased ERRF expression was significantly associated with ER or progesterone receptor (PR) positivity even in HER2-negative tumors. This higher ERRF expression correlated with better disease-free survival and overall survival. In two ER-positive breast cancer cell lines, knockdown of ERRF suppressed cell growth in vitro and tumorigenesis in xenograft models, suggesting that ERRF plays a role in estrogen-ER-mediated breast cancer cell growth and may thus be a potential therapeutic target.

NCBI Gene ID

149563

Swiss Prot

Q8NEQ6

Accession Number

NP_849162

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

ERRF Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/mL

Buffer

ERRF Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

ERRF antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Symbol

C1orf64

Positive Control 2

Cat. No. 1288 - A20 Cell Lysate

Positive Control 3

Cat. No. 17-001 - HeLa Cell Slide

NCBI Official Name

Chromosome 1 open reading frame 64

NCBI Organism

Homo sapiens

Background Reference 01

Su D, Fu X, Fan S, et al. Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells. Am. J. Pathol. 2012; 180:1189-201.