CLEC2A Antibody

Product Specifications

Background

CLEC2A Antibody: CLEC2A (C-type lectin domain family 2 member A), also known as PILAR (proliferation-induced lymphocyte-associated receptor) is involved in modulating T-cell expansion. It is a 32 kDa single-pass type II membrane protein that contains one C-type lectin domain in its extracellular region and belongs to the CTL/CTLD superfamily. CLEC2A is mainly expressed in skin and highly expressed in CD8 (+), B lymphocytes and naive CD4 (+) T cells. Manipulation of CLEC2A signaling may be important for treatment of autoimmune diseases and cancer.

NCBI Gene ID

387836

Swiss Prot

Q6UVW9

Accession Number

NP_001124183

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

CLEC2A Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1204 - K562 Cell Lysate

Concentration

1 mg/mL

Buffer

CLEC2A Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

CLEC2A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

CLEC2A antibody is human specific. Two alternatively spliced transcript variants have been observed.

Symbol

CLEC2A

Positive Control 2

Cat. No. 17-004 - K-562 Cell Slide

NCBI Official Name

C-type lectin domain family 2, member A

NCBI Organism

Homo sapiens

Background Reference 01

Huarte E, Cubillos-Ruiz JR, Nesbeth YC, et al. PILAR is a novel modulator of human T-cell expansion. Blood 2008; 112:1259-68.

Background Reference 02

Drickamer K. C-type lectin-like domains. Curr. Opin. Struct. Biol. 1999; 9:585-90

Background Reference 03

Spreu J, Kienle EC, Schrage B, et al. CLEC2A: a novel, alternatively spliced and skin-associated member of the NKC-encoded AICL-CD69-LLT1 family. Immunogenetics 2007; 59:903-12.

Background Reference 04

Spreu J, Kuttruff S, Stejfova V, et al. Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. Proc. Natl. Acad. Sci. USA 2010; 107:5100-5.