Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

PIAS3 Antibody

Product Specifications

Background

PIAS3 Antibody: The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS3. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS3 binds specifically to STAT3 following the stimulation of STAT3. Increased expression of PIAS3 has been observed in several human cancers, including lung, breast, and brain tumors, but not in anaplastic lymphoma kinase-positive T/null-cell lymphomas, indicating that PIAS3 plays multiple roles in different tissue and cell types.

NCBI Gene ID

10401

Swiss Prot

Q9Y6X2

Accession Number

NP_006090

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

PIAS3 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1204 - K562 Cell Lysate

Concentration

1 mg/mL

Buffer

PIAS3 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PIAS3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=5745

Fragment

IgG

Symbol

PIAS3

NCBI Official Name

Protein inhibitor of activated STAT, 3

NCBI Organism

Homo sapiens

Background Reference 01

Shuai K and Liu B. Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat. Rev. Immunol.2005; 5:593-605.

Background Reference 02

Chung CD, Liao J, Liu B, et al. Specific inhibition of Stat3 signal transduction by PIAS3. Science1997; 278:1803-5.

Background Reference 03

Wang L and Banerjee S. Differential PIAS3 expression in human malignancy. Oncol. Rep.2004; 11:1319-24.

Background Reference 04

Zhang Q, Raghunath PN, Xue L, et al. Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma. J. Immunol.2002; 168:466-7

Other Product Names

PIAS3 Antibody: ZMIZ5, E3 SUMO-protein ligase PIAS3, Protein inhibitor of activated STAT protein 3

Tested Applications

ELISA, WB, IHC-P

Protein ID

115298686

Physical Properties

Liquid

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

2- Chloro- 8- n- hexylaminoadenosine- 3', 5'- cyclic monophosphate (2-Cl-8-HA-cAMP)
MBS256390-01 5 µmol

2- Chloro- 8- n- hexylaminoadenosine- 3', 5'- cyclic monophosphate (2-Cl-8-HA-cAMP)

Ask
View Details
2- Chloro- 8- n- hexylaminoadenosine- 3', 5'- cyclic monophosphate (2-Cl-8-HA-cAMP)
MBS256390-02 5x 5 µmol

2- Chloro- 8- n- hexylaminoadenosine- 3', 5'- cyclic monophosphate (2-Cl-8-HA-cAMP)

Ask
View Details
PFN1-set siRNA/shRNA/RNAi Lentivector (Human)
36438091 4 x 500 ng

PFN1-set siRNA/shRNA/RNAi Lentivector (Human)

Ask
View Details
FAM13A Adenovirus (Human)
19781051 1.0 ml

FAM13A Adenovirus (Human)

Ask
View Details
Mouse Monoclonal Human Coronavirus Spike Protein Antibody (07) [Alexa Fluor 700]
NBP3-14665AF700 0.1 mL

Mouse Monoclonal Human Coronavirus Spike Protein Antibody (07) [Alexa Fluor 700]

Ask
View Details
Mouse Monoclonal Mer Antibody (MERTK/3023) [Allophycocyanin]
NBP3-14234APC 0.1 mL

Mouse Monoclonal Mer Antibody (MERTK/3023) [Allophycocyanin]

Ask
View Details