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CX3CR1 Antibody

Product Specifications

Background

CX3CR1 Antibody: CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was initially identified as the receptor for the transmembrane molecule fractalkine, and renamed CX3CR1. CX3CR1 is known to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration and adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines.

NCBI Gene ID

1524

Swiss Prot

P49238

Accession Number

NP_001328

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Chemokines & Cytokines, Cancer

Purification

CX3CR1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1208 - THP-1 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rat: (100%), Rabbit: (93%), Mouse: (93%), Bovine: (86%)

Buffer

CX3CR1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

CX3CR1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=2201

Fragment

IgG

Specificity

At least two isoforms of CX3CR1 are known to exist.

Symbol

CX3CR1

Positive Control 2

Cat. No. 1212 - 3T3 Cell Lysate

Positive Control 3

Cat. No. 17-008 - THP-1 Cell Slide

NCBI Official Name

Chemokine (C-X3-C motif) receptor 1

NCBI Organism

Homo sapiens

Background Reference 01

Raport CJ, Schweickart VL, Eddy RL JR, et al. The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues. Gene 1995; 163:295-9

Background Reference 02

Combadiere C, Ahuja SK , and Murphy PM. Cloning, chromosomal localization, and RNA expression of a human β chemokine receptor-like gene. DNA Cell Biol. 1995;14:673-80

Background Reference 03

Combadiere C, Gao J, Tiffany HL, et al. Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine. Biochem. Biophys. Res. Commun. 1998; 253:728-32

Background Reference 04

Harrison JK, Barber CM, and Lynch KR. cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors. Neurosci. Lett. 1994; 169:85-9

Other Product Names

CX3CR1 Antibody: V28, CCRL1, GPR13, CMKDR1, GPRV28, CMKBRL1, CX3C chemokine receptor 1, Beta chemokine receptor-like 1, C-X3-C CKR-1

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

4503171

Physical Properties

Liquid

Available Sizes

Curated Selection

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