COPS8 (NM_198189) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Synonyms
COP9; CSN8; SGN8
Gene ID
10920
UniProt
Q99627
Accession Number mRNA
NM_198189
Chromosomal Location
2q37.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
17.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
COPS8
Species
Human
Protein ID
NP_937832
Overview
Recombinant protein of human COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) (COPS8), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/10920
Uniprot URL
https://www.uniprot.org/uniprot/Q99627
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_198189
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_937832
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