DCUN1D5 (NM_032299) Human Recombinant Protein
Product Specifications
Background
Contributes to the neddylation of all cullins by transfering NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs) (PubMed:26906416, PubMed:23201271, PubMed:19617556) . May play a role in DNA damage response and may participate to cell proliferation and anchorage-independent cell growth (PubMed:23098533, PubMed:24192928) .[UniProtKB/Swiss-Prot Function]
Synonyms
SCCRO5
Gene ID
84259
UniProt
Q9BTE7, A0A024R3A2
Accession Number mRNA
NM_032299
Chromosomal Location
11q22.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
27.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
DCUN1D5
Species
Human
Protein ID
NP_115675
Overview
Recombinant protein of human DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae) (DCUN1D5)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/84259
Uniprot URL
https://www.uniprot.org/uniprot/Q9BTE7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_032299
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_115675
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