RASD2 (NM_014310) Human Recombinant Protein
Product Specifications
Background
This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO) . This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD) . Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]
Synonyms
Rhes; TEM2
Gene ID
23551
UniProt
Q96D21
Accession Number mRNA
NM_014310
Chromosomal Location
22q12.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
30.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RASD2
Species
Human
Protein ID
NP_055125
Overview
Recombinant protein of human RASD family, member 2 (RASD2)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/23551
Uniprot URL
https://www.uniprot.org/uniprot/Q96D21
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014310
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055125
Curated Selection
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