L Kynurenine Hydrolase (KYNU) (NM_001032998) Human Recombinant Protein
Product Specifications
Background
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Synonyms
KYNUU; VCRL2
Gene ID
8942
UniProt
Q16719
Accession Number mRNA
NM_001032998
Chromosomal Location
2q22.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Metabolic pathways, Tryptophan metabolism
Field of Research
Metabolic pathways, Tryptophan metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Protease
Molecular Weight
34.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
KYNU
Species
Human
Protein ID
NP_001028170
Overview
Recombinant protein of human kynureninase (L-kynurenine hydrolase) (KYNU), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8942
Uniprot URL
https://www.uniprot.org/uniprot/Q16719
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001032998
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001028170
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