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P27 KIP 1 (CDKN1B) (NM_004064) Human Recombinant Protein

Product Specifications

Background

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4) . [provided by RefSeq, Apr 2014]

Synonyms

CDKN4; KIP1; MEN1B; MEN4; P27KIP1

Gene ID

1027

UniProt

P46527, Q6I9V6

Accession Number mRNA

NM_004064

Chromosomal Location

12p13.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer

Field of Research

Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

21.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

CDKN1B

Species

Human

Protein ID

NP_004055

Overview

Recombinant protein of human cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/1027

Uniprot URL

https://www.uniprot.org/uniprot/P46527

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_004064

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_004055

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