PGD (NM_002631) Human Recombinant Protein

Product Specifications

Background

6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

Overview

Recombinant protein of human phosphogluconate dehydrogenase (PGD)

Synonyms

6PGD

Gene ID

5226

UniProt

P52209

Accession Number mRNA

NM_002631

Chromosomal Location

1p36.22

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Glutathione metabolism, Metabolic pathways, Pentose phosphate pathway

Field of Research

Glutathione metabolism, Metabolic pathways, Pentose phosphate pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

53 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.