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PCNA (NM_002592) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]

Synonyms

ATLD2

Gene ID

5111

UniProt

P12004

Accession Number mRNA

NM_002592

Chromosomal Location

20p12.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Base excision repair, Cell cycle, DNA replication, Mismatch repair, Nucleotide excision repair

Field of Research

Base excision repair, Cell cycle, DNA replication, Mismatch repair, Nucleotide excision repair

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Stem cell - Pluripotency

Molecular Weight

28.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PCNA

Species

Human

Protein ID

NP_002583

Overview

Recombinant protein of human proliferating cell nuclear antigen (PCNA), transcript variant 1

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/5111

Uniprot URL

https://www.uniprot.org/uniprot/P12004

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_002592

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_002583

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