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ITPKA (NM_002220) Human Recombinant Protein

Product Specifications

Background

Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins (1,3,4,5) P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

Synonyms

IP3-3KA; IP3KA

Gene ID

3706

UniProt

P23677

Accession Number mRNA

NM_002220

Chromosomal Location

15q15.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Calcium signaling pathway, Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

Field of Research

Calcium signaling pathway, Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

50.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

ITPKA

Species

Human

Protein ID

NP_002211

Overview

Recombinant protein of human inositol 1, 4, 5-trisphosphate 3-kinase A (ITPKA)

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3706

Uniprot URL

https://www.uniprot.org/uniprot/P23677

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_002220

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_002211

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