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HSD3B2 (NM_000198) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta (5) -ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

Synonyms

HSD3B; HSDB; SDR11E2

Gene ID

3284

UniProt

P26439, A0A024R0F9

Accession Number mRNA

NM_000198

Chromosomal Location

1p12

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Androgen and estrogen metabolism, C21-Steroid hormone metabolism, Metabolic pathways

Field of Research

Androgen and estrogen metabolism, C21-Steroid hormone metabolism, Metabolic pathways

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

41.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

HSD3B2

Species

Human

Protein ID

NP_000189

Overview

Recombinant protein of human hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (HSD3B2)

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3284

Uniprot URL

https://www.uniprot.org/uniprot/P26439

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000198

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000189

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