TIE1 (NM_005424) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Synonyms
JTK14; LMPHM11; TIE
Gene ID
7075
UniProt
P35590
Accession Number mRNA
NM_005424
Chromosomal Location
1p34.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase, Transmembrane
Molecular Weight
124.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TIE1
Species
Human
Protein ID
NP_005415
Overview
Recombinant protein of human tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE1)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7075
Uniprot URL
https://www.uniprot.org/uniprot/P35590
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005424
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005415
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