PRAME (NM_206955) Human Recombinant Protein
Product Specifications
Background
This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Synonyms
CT130; MAPE; OIP-4; OIP4
Gene ID
23532
UniProt
P78395, A0A024R1E6, B7Z986
Accession Number mRNA
NM_206955
Chromosomal Location
22q11.22
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
57.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PRAME
Species
Human
Protein ID
NP_996838
Overview
Purified recombinant protein of Homo sapiens preferentially expressed antigen in melanoma (PRAME), transcript variant 4
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/23532
Uniprot URL
https://www.uniprot.org/uniprot/P78395
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_206955
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_996838
Curated Selection
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